Mewgenics vs Slay the Spire 2
Both are 2026 roguelite strategy games, but one is a turn-based cat-breeding marathon while the other is a tight deckbuilder you finish in 30 minutes.
Makes good on the decade-long Mewgenics dev cycle — McMillen and Glaiel's cat-genetics roguelite hits Isaac territory at 89 MC and 94% recommend.
Still the best deckbuilder roguelite — Mega Crit's sequel deepens the relics and events without breaking the original's perfect 30-min run-shape, on co-op now too.
Steam popularity
Shared scale — sparklines are directly comparable across both games.
Mewgenics
Jun 2026 peak CCU 7,946 ↓ 41% MoM
All-time peak 115,063
Slay the Spire 2
Jun 2026 peak CCU 151,838 ↓ 34% MoM
All-time peak 574,638
Key differences
Core loop
Mewgenics is turn-based cat breeding where you manipulate genetics across generations for 200+ hour runs.
Slay the Spire 2 is a deckbuilder with 30-minute runs, deepening relics and events from the original.
Meta-progression
Mewgenics demands long-term commitment to breeding lines and unlocking, pacing runs over hundreds of hours.
Slay the Spire 2 keeps each run self-contained, with unlocks that don't force a 200-hour grind.
Co-op support
Mewgenics is solo-only at launch, with no co-op mode planned.
Slay the Spire 2 adds asynchronous co-op without breaking the single-player experience.
Which one is for you?
Pick Mewgenics if
- You loved Binding of Isaac and want a turn-based roguelite with deep genetics.
- You have hundreds of hours to invest in a single meta-progression loop.
- You enjoy edgy humor and don't mind gross-out aesthetics in strategy games.
Pick Slay the Spire 2 if
- You want a deckbuilder you can play in short sessions with clear 30-minute runs.
- You're new to roguelites and want a digestible entry point without long grinding.
- You want co-op deckbuilding that respects asynchronous play.
Bottom line
Choose Slay the Spire 2 if you have limited time or want co-op; choose Mewgenics if you want a deep, long-term strategic grind in McMillen's style.