Mewgenics

A cat-genetics roguelite where you breed mutant cats through genetic experiments and take them into turn-based battles to upgrade your cat army.

Last reviewed: May 4, 2026
Released Feb 2026 Strategy

Makes good on the decade-long Mewgenics dev cycle — McMillen and Glaiel's cat-genetics roguelite hits Isaac territory at 89 MC and 94% recommend.

8.9 /10
Strong

For you if

  • You loved Binding of Isaac's runs and want McMillen/Glaiel's turn-based pivot
  • You're a Slay-the-Spire/Inscryption fan curious about cat-genetics meta-progression
  • You can pace 200+ hour run cycles without burnout

Not for you if

  • You bounce off Isaac-style edgy humor and gross-out aesthetics
  • You want a 10-hour finishable single-player without meta-grind
  • You don't have a PC — Mewgenics is PC-only at launch (no console)
What players love

The cat-breeding loop's mutation chains and roguelike adventure variety are what 200-hour fans replay for.

What frustrates them

The brutality of losing a well-bred cat line is the wall that ends many long playthroughs.

See the reviews behind this →

Media

What critics say

  1. 92/100PC Gamer
    A sprawling, ridiculous, and endlessly surprising roguelike that will drag you body and soul into its chaotic world.
    Robin ValentineFeb 2026 Read review →
  2. 9/10IGN
    Mewgenics is a fantastic tactical RPG that's good for more than a hundred hours of roguelike runs.
    Dan StapletonFeb 2026 Read review →
  3. 9/10GameSpot
    What McMillen, Glaiel, and co. pulled off is simply paw-some.

Before You Play

Refreshed monthly
How to complete the Caves with a Collarless cat in Mewgenics?

To complete the Caves with a Collarless cat, the cat must be in your party from the start of the adventure. Completing the Caves with a Collarless cat unlocks the Metronome active ability, which casts a random spell from the game's ability pool. Picking up a Collarless cat mid-run will not work for this unlock.

Source: Mewgenics Wiki

How to beat Boneyard with Thief in Mewgenics?

To beat the Boneyard with the Thief, utilize the class's agility and movement skills to evade undead creatures. The Thief's kit allows for speedy attacks and backstabbing, which can be effective against the skeletons, zombies, and spirits in the Boneyard. Additionally, breaking destructible Gravestones can trigger risk-reward outcomes, such as dropping coins or summoning enemies.

Source: Mewgenics Wiki

How to unlock all areas with the Mage in Mewgenics?

The provided sources do not specifically mention the Mage, but to unlock areas in Mewgenics, complete the previous area for the first time. For example, complete The Alley to unlock The Sewers, and complete The Sewers to unlock The Caves.

Source: Mewgenics Wiki

How do you complete The Core with the Tank in Mewgenics?

To complete The Core with the Tank, utilize the Tank's knockback-focused toolkit to control enemy positioning and keep pressure off your party. The Tank's basic attack can be used as a knockback tool, and its abilities can redirect enemy aggression toward itself. Additionally, The Core area features pools of lava and hellish demons, so be prepared to face these challenges.

Source: Mewgenics Wiki

How to beat the Moon level with the Cleric in Mewgenics?

To beat the Moon level with the Cleric, utilize the Cleric's healing abilities to counter the alien enemies' psychic and gravity-based attacks. The low gravity environment affects movement and projectile trajectories, so adjust your strategy accordingly. The Cleric's resurrection ability can also be crucial in this level.

Source: Mewgenics Wiki

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